Systems Biomedicine

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Systems Biomedicine

Systems Biomedicine
  • Author : Edison T. Liu,Douglas A. Lauffenburger
  • Publisher :
  • Release Date :2009-09-17
  • Total pages :448
  • ISBN : 9780080919836
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Summary : Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems

Comprehensive Systems Biomedicine

Comprehensive Systems Biomedicine
  • Author : Pietro Lio,Enrico Capobianco
  • Publisher :
  • Release Date :2014-12-03
  • Total pages :113
  • ISBN : 2889193748
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Summary : Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.

New Challenges for Cancer Systems Biomedicine

New Challenges for Cancer Systems Biomedicine
  • Author : Alberto D'Onofrio,Paola Cerrai,Alberto Gandolfi
  • Publisher :
  • Release Date :2013-01-25
  • Total pages :400
  • ISBN : 8847025710
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Summary : The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.

Complex Systems in Biomedicine

Complex Systems in Biomedicine
  • Author : A. Quarteroni,L. Formaggia,A. Veneziani
  • Publisher :
  • Release Date :2007-03-20
  • Total pages :292
  • ISBN : 8847003962
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Summary : Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar,respiratory,skeletalandnervoussystems,aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular to the description of tumor growth. The integration of models aimed at simulating the cooperation and interrelation of different systems is an even more dif?cult task. It calls for the setting up of, for instance, interaction models for the integrated cardio-vascular system and the interplay between the central circulation and peripheral compartments, models for the mid-to-long range cardiovascular adjustments to pathological conditions (e.g., to account for surgical interventions, congenital malformations, or tumor growth), models for integration among circulation, tissue perfusion, biochemical and thermal regulation, models for parameter identi?cation and sensitivity analysis to parameter changes or data uncertainty – and many others.

Biomedicine and Alternative Healing Systems in America

Biomedicine and Alternative Healing Systems in America
  • Author : Hans A. Baer
  • Publisher :
  • Release Date :2001
  • Total pages :222
  • ISBN : 9780299166946
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Summary : Examining medical pluralism in the United States from the Revolutionary War period through the end of the twentieth century, Hans Baer brings together in one convenient reference a vast array of information on healing systems as diverse as Christian Science, osteopathy, acupuncture, evangelical faith healing, Santeria, southern Appalachian herbalism, and Navajo healing. In a country where the dominant paradigm of biomedicine (medical schools, research hospitals, clinics staffed by M.D.s and R.N.s) has been long established and supported by laws and regulations, the continuing appeal of other medical systems and subsystems bears careful consideration. Distinctions of class, Baer emphasizes, as well as differences in race, ethnicity, and gender, are fundamental to the diversity of beliefs, techniques, and social organizations represented in the phenomenon of medical pluralism. Baer traces the simultaneous emergence in the nineteenth century of formalized biomedicine and of homeopathy, botanic medicine, hydropathy, Christian Science, osteopathy, and chiropractic. He examines present-day osteopathic medicine as a system parallel to biomedicine; chiropractic, naturopathy, and acupunctur

Metadata-driven Software Systems in Biomedicine

Metadata-driven Software Systems in Biomedicine
  • Author : Prakash M. Nadkarni
  • Publisher :
  • Release Date :2011-05-27
  • Total pages :396
  • ISBN : 9780857295101
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Summary : While the use of database technology is ubiquitous throughout IT (and health IT in particular), it is not generally appreciated that, as a database increases in scope, certain designs are far superior to others. In biomedical domains, new knowledge is being generated continually, and the databases that must support areas such as clinical care and research must also be able to evolve while requiring minimal or no logical / physical redesign. Appropriately designed metadata, and software designed to utilize it effectively, can provide significant insulation against change. Many of the larger EMR or clinical research database vendors have realized this, but their designs are proprietary and not described in the literature. Consequently, numerous misconceptions abound among individuals who have not had to work with large-scale biomedical systems, and graduates of a health or bioinformatics program may find that they need to unlearn what they were taught in database and software design classes in order to work productively with such systems. A working knowledge of such systems is also important for individuals who are not primarily software developers, such as health informaticians, medical information officers and data analysts. This book is, in a sense, intended to prepare all of the above individuals for the real world.

Complex Systems Science in Biomedicine

Complex Systems Science in Biomedicine
  • Author : Thomas Deisboeck,J. Yasha Kresh
  • Publisher :
  • Release Date :2007-06-13
  • Total pages :864
  • ISBN : 9780387335322
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Summary : Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

Knowledge-Based Systems in Biomedicine and Computational Life Science

Knowledge-Based Systems in Biomedicine and Computational Life Science
  • Author : Tuan D. Pham,Lakhmi C. Jain
  • Publisher :
  • Release Date :2012-12-14
  • Total pages :216
  • ISBN : 3642330150
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Summary : This book presents a sample of research on knowledge-based systems in biomedicine and computational life science. The contributions include: personalized stress diagnosis system, image analysis system for breast cancer diagnosis, analysis of neuronal cell images, structure prediction of protein, relationship between two mental disorders, detection of cardiac abnormalities, holistic medicine based treatment and analysis of life-science data.

A Systems Approach to Biomedicine

A Systems Approach to Biomedicine
  • Author : William B. Blesser
  • Publisher :
  • Release Date :1969
  • Total pages :615
  • ISBN :
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Summary :

Handbook of Research on Informatics in Healthcare and Biomedicine

Handbook of Research on Informatics in Healthcare and Biomedicine
  • Author : Lazakidou, Athina A.
  • Publisher :
  • Release Date :2006-06-30
  • Total pages :479
  • ISBN : 1591409837
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Summary : Describes and analyzes recent breakthroughs in healthcare and biomedicine providing comprehensive coverage and definitions of important issues, concepts, new trends and advanced technologies.

Mathematical Modelling in Biomedicine

Mathematical Modelling in Biomedicine
  • Author : Y. Cherruault
  • Publisher :
  • Release Date :1986-02-28
  • Total pages :258
  • ISBN : 9789027721495
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Summary : Approach your problems from the right It isn't that they can't see the solution. It end and begin with the answers. Then is that they can't see the problem. one day, perhaps you will find the final question. G.K. Chesterton. The Scandal of Father Brown 'The point of a Pin'. 'The Hermit Clad in Crane Feathers' in R. van Gulik's The Chinese Maze Murders. Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the "tree" of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, cod ing theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical pro gramming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces.

Web-Based Applications in Healthcare and Biomedicine

Web-Based Applications in Healthcare and Biomedicine
  • Author : Athina A. Lazakidou
  • Publisher :
  • Release Date :2009-12-18
  • Total pages :271
  • ISBN : 9781441912749
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Summary : Web-based applications provide the power of desktop and server applications with the exibility and accessibility of the web. Using web browsers, users can securely access applications from anywhere within the reach of the company intranet or extranet. The special issue strives to explore the advanced web-based information systems and database applications in healthcare area. Healthcare organizations are undergoing major reorganizations and adjustments to meet the increasing demands of improved healthcare access and quality, as well as lowered costs. As the use of information technology to process medical data increases, much of the critical information necessary to meet these challenges is being stored in digital format. Web-enabled information technologies can provide the means for greater access and more effective integration of healthcare information from disparate computer applications and other information resources. This book presents studies from leading researchers and practitioners focusing on the current challenges, directions, trends, and opportunities associated with heal- care organizations and their strategic use of web-enabled technologies. Managing healthcare information systems with web-enabled technologies is an excellent ve- cle for understanding current and potential uses of Internet technology in the broad areas of healthcare and medical applications.

Future Visions on Biomedicine and Bioinformatics 2

Future Visions on Biomedicine and Bioinformatics 2
  • Author : Lodewijk Bos,Denis Carroll,Luis Kun,Andrew Marsh,Laura M. Roa
  • Publisher :
  • Release Date :2011-07-11
  • Total pages :106
  • ISBN : 9783642195549
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Summary : Swamy Laxminarayan was an outstanding researcher active in many diverse fields of science and technology. He was one of the most prominent biomedical scientists and his ideas influenced the Biomedical Technology substantially. This book tries to provide an overview on the multiple achievements of Swamy Laxminarayan. It presents a collection of his most outstanding publications and an overview on his outstanding life. This Volume is the second part of the liber amicorum in Memory of Swamy Laxminarayan.

Computational Intelligence in Biomedicine and Bioinformatics

Computational Intelligence in Biomedicine and Bioinformatics
  • Author : Tomasz G. Smolinski,Mariofanna G. Milanova,Aboul-Ella Hassanien
  • Publisher :
  • Release Date :2008-10-01
  • Total pages :432
  • ISBN : 9783540707769
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Summary : The purpose of this book is to provide an overview of state-of-the-art methodologies currently utilized for biomedicine and/or bioinformatics-oriented applications. Researchers working in these fields will learn new methods to help tackle their problems.

Fundamentals of Complementary and Alternative Medicine - E-Book

Fundamentals of Complementary and Alternative Medicine - E-Book
  • Author : Marc S. Micozzi
  • Publisher :
  • Release Date :2010-04-01
  • Total pages :624
  • ISBN : 1437727050
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Summary : Focusing on emerging therapies and those best supported by clinical trials and scientific evidence, Fundamentals of Complementary and Alternative Medicine describes some of the most prevalent and the fastest-growing CAM therapies in use today. Prominent author Dr. Marc Micozzi provides a complete overview of CAM, creating a solid foundation and context for therapies in current practice. Coverage of systems and therapies includes mind, body, and spirit; traditional Western healing; and traditional ethnomedical systems from around the world. Discussions include homeopathy, massage and manual therapies, chiropractic, a revised chapter on osteopathy, herbal medicine, aromatherapy, naturopathic medicine, and nutrition and hydration. With its wide range of topics, this is the ideal CAM reference for both students and practitioners! An evidence-based approach focuses on treatments best supported by clinical trials and scientific evidence. Coverage of CAM therapies and systems includes those most commonly encountered or growing in popularity, so you carefully evaluate each treatment. Global coverage includes discussions of traditional healing arts from Europe, Asia, Africa, and the Americas. Longevity in the market makes this a classic, trusted text. Expert contributors include well-known writers such as Kevin Ergil, Patch Adams, Joseph Pizzorno, Victor Sierpina, and Marc Micozzi himself. Suggested readings and references in each chapter list the best resources for further research and study. New, expanded organization covers the foundations of CAM, traditional Western healing, and traditional ethnomedical systems from Asia, Africa, and the Americas, putting CAM in perspective and making it easier to understand CAM origins and contexts. NEW content includes legal and operational issues in integrative medicine, creative and expressive arts therapies, ecological pharmacology, hydration, mind-body thought and practice in America, osteopathy, reflexology, South American healing, traditional medicines of India, and Unani medicine. Revised and updated chapters include aromatherapy, classical acupuncture, energy medicine, biophysical devices (electricity, light, and magnetism), massage and touch therapies, traditional osteopathy, reflexology, vitalism, and yoga. New research studies explain how and why CAM therapies work, and also demonstrate that they do work, in areas such as acupuncture, energy healing, and mind-body therapies. Expanded content on basic sciences includes biophysics, ecology, ethnomedicine, neurobiology, and pschoneuroimmunology, providing the scientific background needed to learn and practice CAM and integrative medicine. Expanded coverage of nutrition and hydration includes practical information on Vitamin D and healthy hydration with fluid and electrolytes.

Basic Feedback Controls in Biomedicine

Basic Feedback Controls in Biomedicine
  • Author : Charles Lessard
  • Publisher :
  • Release Date :2009-05-08
  • Total pages :210
  • ISBN : 1598299514
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Summary : This textbook is intended for undergraduate students (juniors or seniors) in Biomedical Engineering, with the main goal of helping these students learn about classical control theory and its application in physiological systems. In addition, students should be able to apply the Laboratory Virtual Instrumentation Engineering Workbench (LabVIEW) Controls and Simulation Modules to mammalian physiology. The first four chapters review previous work on differential equations for electrical and mechanical systems. Chapters 5 through 8 present the general types and characteristics of feedback control systems and foot locus, frequency response, and analysis of stability and margins. Chapters 9 through 12 cover basic LabVIEW programming, the control module with its pallets, and the simulation module with its pallets. Chapters 13 through 17 present various physiological models with several LabVIEW control analyses. These chapters cover control of the heart (heart rate, stroke volume, and cardiac output), the vestibular system and its role in governing equilibrium and perceived orientation, vestibulo-ocular reflex in stabilizing an image on the surface of the retina during head movement, mechanical control models of human gait (walking movement), and the respiratory control model. The latter chapters (Chapters 13-17) combine details from my class lecture notes in regard to the application of LabVIEW control programming by the class to produce the control virtual instruments and graphical displays (root locus, Bode plots, and Nyquist plot). This textbook was developed in cooperation with National Instruments personnel. Table of Contents: Electrical System Equations / Mechanical Translation Systems / Mechanical Rotational Systems / Thermal Systems and Systems Representation / Characteristics and Types of Feedback Control Systems / Root Locus / Frequency Response Analysis / Stability and Margins / Introduction to LabVIEW / Control Design in LabVIEW / Simulation in LabVIEW / LabVIEW Control Design and Simulation Exercise / Cardiac Control / Vestibular Control System / Vestibulo-Ocular Control System / Gait and Stance Control System / Respiratory Control System

Data Mining, Systems Analysis, and Optimization in Biomedicine

Data Mining, Systems Analysis, and Optimization in Biomedicine
  • Author : Onur Seref,O. Erhun Kundakcioglu,Panos M. Pardalos
  • Publisher :
  • Release Date :2007-11-26
  • Total pages :318
  • ISBN :
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Summary : Gainesville, FL, U.S.A. 28-30 March 2007

Artificial Neural Networks in Biomedicine

Artificial Neural Networks in Biomedicine
  • Author : Paulo J.G. Lisboa,Emmanuel C. Ifeachor,Piotr S. Szczepaniak
  • Publisher :
  • Release Date :2012-12-06
  • Total pages :288
  • ISBN : 1447104870
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Summary : Following the intense research activIties of the last decade, artificial neural networks have emerged as one of the most promising new technologies for improving the quality of healthcare. Many successful applications of neural networks to biomedical problems have been reported which demonstrate, convincingly, the distinct benefits of neural networks, although many ofthese have only undergone a limited clinical evaluation. Healthcare providers and developers alike have discovered that medicine and healthcare are fertile areas for neural networks: the problems here require expertise and often involve non-trivial pattern recognition tasks - there are genuine difficulties with conventional methods, and data can be plentiful. The intense research activities in medical neural networks, and allied areas of artificial intelligence, have led to a substantial body of knowledge and the introduction of some neural systems into clinical practice. An aim of this book is to provide a coherent framework for some of the most experienced users and developers of medical neural networks in the world to share their knowledge and expertise with readers.

Physicians of Western Medicine

Physicians of Western Medicine
  • Author : Robert A. Hahn,Atwood D. Gaines
  • Publisher :
  • Release Date :2012-12-06
  • Total pages :345
  • ISBN : 9400964307
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Summary : After putting down this weighty (in all senses of the word) collection, the reader, be she or he physician or social scientist, will (or at least should) feel uncomfortable about her or his taken-for-granted commonsense (therefore cultural) understanding of medicine. The editors and their collaborators show the medical leviathan, warts and all, for what it is: changing, pluralistic, problematic, powerful, provocative. What medicine proclaims itself to be - unified, scientific, biological and not social, non-judgmental - it is shown not to resemble very much. Those matters about which medicine keeps fairly silent, it turns out, come closer to being central to its clinical practice - managing errors and learning to conduct a shared moral dis course about mistakes, handling issues of competence and competition among biomedical practitioners, practicing in value-laden contexts on problems for which social science is a more relevant knowledge base than biological science, integrating folk and scientific models of illness in clinical communication, among a large number of highly pertinent ethnographic insights that illuminate medicine in the chapters that follow.

Information Retrieval in Biomedicine: Natural Language Processing for Knowledge Integration

Information Retrieval in Biomedicine: Natural Language Processing for Knowledge Integration
  • Author : Prince, Violaine,Roche, Mathieu
  • Publisher :
  • Release Date :2009-03-31
  • Total pages :460
  • ISBN : 1605662755
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Summary : "This book provides relevant theoretical frameworks and the latest empirical research findings in biomedicine information retrieval as it pertains to linguistic granularity"--Provided by publisher.