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Patient H.M.

  • Author : Luke Dittrich
  • Publisher :
  • Release Date :2016-08-09
  • Total pages :480
  • ISBN : 067964380X

Summary : “Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. Praise for Patient H.M. “An exciting, artful blend of family and medical history.”—The New York Times “In prose both elegant and intimate, and often thrilling, Patient H.M. is an important book about the wages not of sin but of science.”—The Washington Post “Spellbinding . . . The fact that Dittrich looks critically at the actual process of scientific investigation is just one of the things to admire about Patient H.M.”—The New York Times Book Review “Patient H.M. tells one of the most fascinating and disturbing stories in the annals of medicine, weaving in ethics, philosophy, a personal saga, the history of neurosurgery, the mysteries of human memory, and an exploration of human ego.”—Sheri Fink, M.D., Pulitzer Prize winner and author of Five Days at Memorial “This is classic reporting and myth-making at the same time.”—Colum McCann, author of Let the Great World Spin *Kirkus Reviews (starred review)

Permanent Present Tense

  • Author : Suzanne Corkin
  • Publisher :
  • Release Date :2013-05-14
  • Total pages :384
  • ISBN : 0465033490

Summary : In 1953, 27-year-old Henry Gustave Molaison underwent an experimental “psychosurgical” procedure—a targeted lobotomy—in an effort to alleviate his debilitating epilepsy. The outcome was unexpected—when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry’s tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry’s crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry—known only by his initials H. M. until his death in 2008—stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain. Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.

Remembering

  • Author : Donald G. MacKay
  • Publisher :
  • Release Date :2019-01-29
  • Total pages :400
  • ISBN : 1633884082

Summary : The psychologist who worked with a famous amnesiac patient for fifty years explains what his studies show about how memory functions and ways to keep the brain sharp. At age twenty-seven, Henry Molaison underwent brain surgery to remedy life-threatening epilepsy. This operation inadvertently destroyed his hippocampus, the engine in the brain for forming new memories. Henry--until recently, known only as Patient H.M.--suffered catastrophic memory failures for the rest of his life and he became the most studied amnesia patient in the history of the world. Dr. Donald MacKay's studies with Henry span fifty years. They reveal the profound importance of memory. Memory decline impacts everything that makes a normal human mind and brain worth having: creative expression; artistic endeavors; awareness; and the ability to plan, to comprehend, to detect and correct errors, to appreciate humor, to imagine hypothetical situations, and to perceive novelty in the world. His research also shows how to keep memories sharp at any age and how to offset the degradation that aging and infrequent use inflict on memory. Remembering summarizes other results of the revolution in scientific understanding of mind and memory that began with Henry. Importantly, it makes good on the promise that research with Henry would help others by focusing on what readers who wish to maintain the everyday functioning of memory, mind, and brain (their own or others') can learn from the still ongoing revolution that he inspired.

Patient H.M.

  • Author : Luke Dittrich
  • Publisher :
  • Release Date :2016-08-09
  • Total pages :480
  • ISBN : 067964380X

Summary : “Oliver Sacks meets Stephen King”* in this propulsive, haunting journey into the life of the most studied human research subject of all time, the amnesic known as Patient H.M. For readers of The Immortal Life of Henrietta Lacks comes a story that has much to teach us about our relentless pursuit of knowledge. Winner of the PEN/E.O. Wilson Literary Science Writing Award • Los Angeles Times Book Prize Winner NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Washington Post • New York Post • NPR • The Economist • New York • Wired • Kirkus Reviews • BookPage In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today. Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves. Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide. Praise for Patient H.M. “An exciting, artful blend of family and medical history.”—The New York Times “In prose both elegant and intimate, and often thrilling, Patient H.M. is an important book about the wages not of sin but of science.”—The Washington Post “Spellbinding . . . The fact that Dittrich looks critically at the actual process of scientific investigation is just one of the things to admire about Patient H.M.”—The New York Times Book Review “Patient H.M. tells one of the most fascinating and disturbing stories in the annals of medicine, weaving in ethics, philosophy, a personal saga, the history of neurosurgery, the mysteries of human memory, and an exploration of human ego.”—Sheri Fink, M.D., Pulitzer Prize winner and author of Five Days at Memorial “This is classic reporting and myth-making at the same time.”—Colum McCann, author of Let the Great World Spin *Kirkus Reviews (starred review)

Summary and Analysis of Patient H.M.: A Story of Memory, Madness, and Family Secrets

  • Author : Worth Books
  • Publisher :
  • Release Date :2017-05-16
  • Total pages :30
  • ISBN : 1504046463

Summary : So much to read, so little time? This brief overview of Patient H.M. tells you what you need to know—before or after you read Luke Dittrich’s book. Crafted and edited with care, Worth Books set the standard for quality and give you the tools you need to be a well-informed reader. This short summary and analysis of Patient H.M.: A Story of Memory, Madness, and Family Secrets includes: Historical context Chapter-by-chapter overviews Profiles of the main characters Detailed timeline of key events Important quotes Fascinating trivia Glossary of terms Supporting material to enhance your understanding of the original work About Patient H.M. by Luke Dittrich: Patient H.M. tells the extraordinary true story of Henry Molaison, a young man who underwent a lobotomy in 1953 in hopes of curing his epilepsy. Instead, he suffered extensive memory loss and would became the most studied patient in the history of neuroscience. Luke Dittrich, whose grandfather performed the surgery, artfully combines family history, medical science, and investigative journalism to create a suspenseful and unsettling narrative on the search to understand the most elusive of scientific research topics: the human memory. The summary and analysis in this ebook are intended to complement your reading experience and bring you closer to a great work of nonfiction.

The History of Neuroscience in Autobiography

  • Author : Larry R. Squire
  • Publisher :
  • Release Date :1998-10-16
  • Total pages :433
  • ISBN : 0080534058

Summary : This book is the second volume of autobiographical essays by distinguished senior neuroscientists; it is part of the first collection of neuroscience writing that is primarily autobiographical. As neuroscience is a young discipline, the contributors to this volume are truly pioneers of scientific research on the brain and spinal cord. This collection of fascinating essays should inform and inspire students and working scientists alike. The general reader interested in science may also find the essays absorbing, as they are essentially human stories about commitment and the pursuit of knowledge. The contributors included in this volume are: Lloyd M. Beidler, Arvid Carlsson, Donald R. Griffin, Roger Guillemin, Ray Guillery, Masao Ito. Martin G. Larrabee, Jerome Lettvin, Paul D. MacLean, Brenda Milner, Karl H. Pribram, Eugene Roberts and Gunther Stent. Key Features * Second volume in a collection of neuroscience writing that is primarily autobiographical * Contributors are senior neuroscientists who are pioneers in the field

Dignity Therapy

  • Author : Harvey Max Chochinov
  • Publisher :
  • Release Date :2012-01-04
  • Total pages :199
  • ISBN : 0195176219

Summary : Maintaining dignity for patients approaching death is a core principle of palliative care. Dignity therapy, a psychological intervention developed by Dr. Harvey Max Chochinov and his internationally lauded research group, has been designed specifically to address many of the psychological, existential, and spiritual challenges that patients and their families face as they grapple with the reality of life drawing to a close. In the first book to lay out the blueprint for this unique and meaningful intervention, Chochinov addresses one of the most important dimensions of being human. Being alive means being vulnerable and mortal; he argues that dignity therapy offers a way to preserve meaning and hope for patients approaching death. With history and foundations of dignity in care, and step by step guidance for readers interested in implementing the program, this volume illuminates how dignity therapy can change end-of-life experience for those about to die - and for those who will grieve their passing.

The Man Who Mistook His Wife For A Hat: And Other Clinical Tales

  • Author : Oliver Sacks
  • Publisher :
  • Release Date :1998
  • Total pages :243
  • ISBN : 0684853949

Summary : Presents a series of stories about men and women who, representing both medical and literary oddities, raise fundamental questions about the nature of reality

The Telling Room

  • Author : Michael Paterniti
  • Publisher :
  • Release Date :2013-07-30
  • Total pages :368
  • ISBN : 081299454X

Summary : NEW YORK TIMES BESTSELLER • NAMED ONE OF THE BEST BOOKS OF THE YEAR BY NPR • Entertainment Weekly • Kirkus Reviews • The Christian Science Monitor In the picturesque village of Guzmán, Spain, in a cave dug into a hillside on the edge of town, an ancient door leads to a cramped limestone chamber known as “the telling room.” Containing nothing but a wooden table and two benches, this is where villagers have gathered for centuries to share their stories and secrets—usually accompanied by copious amounts of wine. It was here, in the summer of 2000, that Michael Paterniti found himself listening to a larger-than-life Spanish cheesemaker named Ambrosio Molinos de las Heras as he spun an odd and compelling tale about a piece of cheese. An unusual piece of cheese. Made from an old family recipe, Ambrosio’s cheese was reputed to be among the finest in the world, and was said to hold mystical qualities. Eating it, some claimed, conjured long-lost memories. But then, Ambrosio said, things had gone horribly wrong. . . . By the time the two men exited the telling room that evening, Paterniti was hooked. Soon he was fully embroiled in village life, relocating his young family to Guzmán in order to chase the truth about this cheese and explore the fairy tale–like place where the villagers conversed with farm animals, lived by an ancient Castilian code of honor, and made their wine and food by hand, from the grapes growing on a nearby hill and the flocks of sheep floating over the Meseta. What Paterniti ultimately discovers there in the highlands of Castile is nothing like the idyllic slow-food fable he first imagined. Instead, he’s sucked into the heart of an unfolding mystery, a blood feud that includes accusations of betrayal and theft, death threats, and a murder plot. As the village begins to spill its long-held secrets, Paterniti finds himself implicated in the very story he is writing. Equal parts mystery and memoir, travelogue and history, The Telling Room is an astonishing work of literary nonfiction by one of our most accomplished storytellers. A moving exploration of happiness, friendship, and betrayal, The Telling Room introduces us to Ambrosio Molinos de las Heras, an unforgettable real-life literary hero, while also holding a mirror up to the world, fully alive to the power of stories that define and sustain us. Praise for The Telling Room “Captivating . . . Paterniti’s writing sings, whether he’s talking about how food activates memory, or the joys of watching his children grow.”—NPR

The Auxiliary Nurse

  • Author : H. M. Erasmus,Liezel Booysen,Van Zyl, M. D. (Magda)
  • Publisher :
  • Release Date :2004-03
  • Total pages :406
  • ISBN : 9780702166433

Summary : "The Auxiliary Nurse" covers the entire curriculum for learners preparing to write the South African Nursing Council (SANC) examination. Arranged in learning units, the book uses an outcomes based educational strategy to guide both learners and lecturers to essential information. This richly illustrated text has sections on the history of nursing, anatomy and physiology, basic nursing, food and nutrition, first aid and comprehensive health care, which has a strong emphasis on community nursing.

Empathy and the Practice of Medicine

  • Author : Howard M. Spiro,Mary G. McCrea Curnen,Enid Peschel,Deborah St. James
  • Publisher :
  • Release Date :1996
  • Total pages :208
  • ISBN : 9780300066708

Summary : The book - which includes essays by physicians, philosophers, and a nurse - is divided into three parts: one deals with how empathy is weakened or lost during the course of medical education and suggests how to remedy this; another describes the historical and philosophical origins of empathy and provides arguments for and against it; and a third section offers compelling accounts of how physicians' empathy for their patients has affected their own lives and the lives of those in their care. We hear, for example, from a physician working in a hospice who relates the ways that the staff try to listen and respond to the needs of the dying; a scientist who interviews candidates for medical school and tells how qualities of empathy are undervalued by selection committees; a nurse who considers what nursing can teach physicians about empathy; another physician who ponders whether the desire to be empathic can hinder the detachment necessary for objective care; and several contributors who show how literature and art can help physicians to develop empathy.

Trouble in Mind

  • Author : Jenni Ogden PhD
  • Publisher :
  • Release Date :2012-02-01
  • Total pages :432
  • ISBN : 0199921431

Summary : In Trouble in Mind, neuropsychologist Jenni Ogden, author of Fractured Minds, transports the reader into the world of some of her most memorable neurological patients as she explores with compassion, insight, and vivid description the human side of brain damage. These are tales of patients who, as the result of stroke, brain tumor, car crash, or neurological disease, begin thinking and behaving strangely, and with their loved ones' support embark on the long journey to recovery, acceptance of disability and sometimes, death. There is Luke, the gang member who loses his speech but finds he can still sing his favorite blues number "Trouble in Mind," and HM, who teaches the world about memory and becomes the most studied single case in medical history. You will meet Julian, who misplaces his internal map of the human body, and Melody, a singer who risks losing her song when she undergoes brain surgery to cure her epilepsy. Then there is Kim with a severe head injury, and Sophie who has just enough time to put her house in order before Alzheimer's dementia steals her insight. For these and the many other patients whose stories are told in this book, the struggle to understand their disordered minds and disobedient bodies takes extraordinary courage, determination, and patience. For health professionals and researchers working with these patients, the ethical and emotional challenges can be as demanding as the intellectual and treatment decisions they make daily. Trouble In Mind is written in an accessible narrative style that is both accurate and intimate. It will be enjoyed by readers -- whether students, researchers, or professionals in mental health and neuroscience, patients with neurological disorders and their families, or general readers -- who want to learn more about brain disorders and the doctors who care for those who suffer them.

Cancer Management in Small Animal Practice - E-Book

  • Author : Carolyn J. Henry,Mary Lynn Higginbotham
  • Publisher :
  • Release Date :2009-12-03
  • Total pages :432
  • ISBN : 1437701981

Summary : Cancer Management in Small Animal Practice provides you with all the tools needed to diagnose, stage, and manage the many different disease entities known as "cancer." This manual is designed to provide you with easy-to-access, clinically relevant details for complete care of the small animal cancer patient, while considering the needs, concerns, and capabilities of the client. It provides quick reference sections for information not included in current oncology texts, including drug interactions and resources for participation in clinical trials. All information is well referenced and the reference section on the accompanying website includes links to the original and related articles. The latest information including diagnostic procedures, treatment modalities, and outcome predictions to help clients make the best decisions for their pets. Expert contributors, renowned for clinical, as well as academic and research expertise, offer a wide breadth and depth of expertise. Full-color format provides accurate visual depictions of specific diseases and procedures to enhance your diagnostic capabilities. Key Points highlight critical information, enabling quick, easy access. Systems approach to diagnosis and management offers logical, systematic, head-to-tail procedure for accurate diagnosis, treatment, and prognosis. Extensive discussions of supportive care limit adverse events and increase patient survival and puts emergency information at the practitioner’s fingertips. Suggested readings highlight the latest information for further investigation and research. Comprehensive drug safety guidelines thoroughly discuss all information required to safely handle and administer cancer drugs. Helpful drug formularies offer available formulations, recommended dosages, toxicities, and relative costs. Chapter on how to access clinical trials provides helpful information and hope for patients and their caregivers.

Creating Modern Neuroscience: The Revolutionary 1950s

  • Author : Gordon M. Shepherd
  • Publisher :
  • Release Date :2010
  • Total pages :291
  • ISBN : 0195391500

Summary : For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.

The Making Of Memory

  • Author : Steven Rose
  • Publisher :
  • Release Date :2012-09-30
  • Total pages :432
  • ISBN : 1446442551

Summary : Steven Rose's The Making of Memory is about just that, in both its senses: the biological processes by which we humans - and other animals - learn and remember, and how researchers can explore these mechanisms. But it is also about much more. When the first edition of this fascinating book won the Science book Prize in 1993, the judges described it as 'a riveting read...a first-hand account by a practicing scientist working at the forefront of medical research and Rose does not duck the issues which that raises.' Now ten years on, research has itself moved forward, and Rose has taken the opportunity to fully revise the book. But this is more than mere revision. Where ten years ago he argued the case for research on memory because it is the most extraordinary of human attributes, Rose's own research has now opened the doors to a potential new treatment for Alzheimer's Disease undreamed of a decade ago, and in an entirely new chapter he describes how this potential breakthrough has occurred.