Natural Hosts Of SIV

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Natural Hosts of SIV

Natural Hosts of SIV
  • Author : Aftab A. Ansari,Guido Silvestri
  • Publisher :
  • Release Date :2014-07-04
  • Total pages :400
  • ISBN : 0124051677
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Summary : Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure

Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure
  • Author : Constantinos Petrovas,Vijayakumar Velu
  • Publisher :
  • Release Date :2019-02-11
  • Total pages :329
  • ISBN : 2889457583
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Summary : Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.

Models of Protection Against HIV/SIV

Models of Protection Against HIV/SIV
  • Author : Gianfranco Pancino,Guido Silvestri,Keith R. Fowke
  • Publisher :
  • Release Date :2012-01
  • Total pages :345
  • ISBN : 0123877156
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Summary : A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

Desk Encyclopedia Animal and Bacterial Virology

Desk Encyclopedia Animal and Bacterial Virology
  • Author : Brian W.J. Mahy,Marc H.V. van Regenmortel
  • Publisher :
  • Release Date :2010-04-06
  • Total pages :646
  • ISBN : 9780123751454
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Summary : This volume contains 81 chapters that relate to veterinary and bacterial virology. The first section describes general features of farm and other animals of agricultural importance. The following three sections detail other animal viruses, avian viruses, and viruses affecting aquatic species such as fish and crustaceans. The Section five deals with viruses which infect bacteria. The most comprehensive single-volume source providing an overview of virology issues related to animal and bateria Bridges the gap between basic undergraduate texts and specialized reviews Concise and general overviews of important topics within the field will help in preparation of lectures, writing reports, or drafting grant applications

AIDS Pathogenesis

AIDS Pathogenesis
  • Author : H. Schuitemaker,Frank Miedema
  • Publisher :
  • Release Date :2000-03-31
  • Total pages :282
  • ISBN : 9780792361961
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Summary : Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Viral Sex

Viral Sex
  • Author : Jaap Goudsmit
  • Publisher :
  • Release Date :1998
  • Total pages :260
  • ISBN : 0195124960
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Summary : Leading AIDS researcher Jaap Goudsmit illuminates the origins and nature of the world's most lethal epidemic. Goudsmit takes us on a journey from the African rainforest to ancient Egypt to pioneering research labs in the U.S. and Europe. Impeccably researched, VIRAL SEX instills readers with a new sense of the urgent need to contain HIV and other similarly lethal viruses. Illustrated.

Simian Virology

Simian Virology
  • Author : Alexander F. Voevodin,Preston A. Marx
  • Publisher :
  • Release Date :2009-08-06
  • Total pages :504
  • ISBN : 9780813809588
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Summary : Simian Virology is the first text to comprehensively cover all currently known simian viruses. Chapters provide an overview of nonhuman primate models of medically important viral diseases as well as natural infections of nonhuman primates with human and animal viruses. The text covers a variety of topics including primate models of medically important viral diseases such as AIDS, hypotheses on the origins of epidemic forms of HIV, and viral diseases caused by non-simian viruses in both wild and captive primates.

Encyclopedia of AIDS

Encyclopedia of AIDS
  • Author : Thomas J. Hope,Douglas Richman,Mario Stevenson
  • Publisher :
  • Release Date :2018-02-22
  • Total pages :2192
  • ISBN : 9781493971008
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Summary : For the first time, the world’s experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are discussed (such as enteric diseases and fungal infections). Typically, the treatment of any given form of pathology is briefly discussed in the entry that covers that illness. The reference is a must-read for Infectious Disease specialists, Immunologists, Public Health researchers, Virologists, Microbiologists, Pharmacologists, and Physicians.

Veterinary Microbiology

Veterinary Microbiology
  • Author : D. Scott McVey,Melissa Kennedy,M. M. Chengappa
  • Publisher :
  • Release Date :2013-05-30
  • Total pages :656
  • ISBN : 111865062X
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Summary : Veterinary Microbiology, Third Edition is a comprehensive reference on the bacterial, fungal, and viral pathogenic agents that cause animal disease. Now in full color with improved images throughout, the new edition has been thoroughly updated to reflect information from current research and diagnostic and clinical publications. Key changes include a review of microbial cell structure and function and increased emphasis on the key points of pathogenesis and host responses to infection. Organized into four sections, the Third Edition begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral diseases and viruses. The final section presents a systematic approach of describing infection and disease of animals. Equally useful for beginning veterinary students and seasoned practitioners, Veterinary Microbiology offers a thorough introduction and reference text for veterinary infectious disease.

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research
  • Author : N.A
  • Publisher :
  • Release Date :1995-08-04
  • Total pages :428
  • ISBN : 0080537642
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Summary : This book represents the most comprehensive publication of its type on nonhuman primates. It also provides basic information on the biology and management of primates for anyone responsible for the care and use of these animals. A related book on primate diseases will be published in 1996. Stresses the following major topics: Biology and medical management Reproductive physiology and breeding Nutrition Biohazards

Human Immunodeficiency Virus Sequence Compendium

Human Immunodeficiency Virus Sequence Compendium
  • Author : N.A
  • Publisher :
  • Release Date :2005
  • Total pages :329
  • ISBN :
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Summary :

Simian Retroviruses—Advances in Research and Application: 2012 Edition

Simian Retroviruses—Advances in Research and Application: 2012 Edition
  • Author : N.A
  • Publisher :
  • Release Date :2012-12-26
  • Total pages :71
  • ISBN : 1481610201
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Summary : Simian Retroviruses—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Simian Retroviruses in a concise format. The editors have built Simian Retroviruses—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Simian Retroviruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Simian Retroviruses—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Occupational Health and Safety in the Care and Use of Nonhuman Primates

Occupational Health and Safety in the Care and Use of Nonhuman Primates
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates
  • Publisher :
  • Release Date :2003-07-13
  • Total pages :180
  • ISBN : 030908914X
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Summary : The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.

Zoonoses, Public Health and the Exotic Animal Practitioner, An Issue of Veterinary Clinics: Exotic Animal Practice - E-Book

Zoonoses, Public Health and the Exotic Animal Practitioner, An Issue of Veterinary Clinics: Exotic Animal Practice - E-Book
  • Author : Marcy J. Souza
  • Publisher :
  • Release Date :2011-09-29
  • Total pages :192
  • ISBN : 1455712086
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Summary : A comprehensive review of zoonoses and public health for the exotic animal practitioner! The issue will cover: zoonoses and preventive medicine practices, rabies, followed by specific, individual chapters on zoonoses associated with invertebrates, fish, reptiles and amphibians, common pet birds, backyard flocks, wild birds, rabbits and rodents, pocket pets, felids & procyonids, and primates and monkeys.

Parasite Diversity and Diversification

Parasite Diversity and Diversification
  • Author : Serge Morand,Boris R. Krasnov,Tim Littlewood,D. Timothy J. Littlewood
  • Publisher :
  • Release Date :2015-02-26
  • Total pages :488
  • ISBN : 1107037654
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Summary : By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.

Encyclopedia of Virology

Encyclopedia of Virology
  • Author : Brian W. J. Mahy,M. H. V. Van Regenmortel
  • Publisher :
  • Release Date :2008
  • Total pages :3020
  • ISBN :
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Summary : Covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria and insects ... this new ed. has been extensively revised and updated to reflect the 50 % increase in identified and accepted viruses since 2000. Includes information on avian flu, SARS and West Nile and the ability of some viruses to be used as agents of bioterrorism.

Wildlife Disease Ecology

Wildlife Disease Ecology
  • Author : Kenneth Wilson,Andy Fenton,Dan Tompkins
  • Publisher :
  • Release Date :2019-11-30
  • Total pages :500
  • ISBN : 1107136563
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Summary : Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.

Foamy Viruses

Foamy Viruses
  • Author : Axel Rethwilm
  • Publisher :
  • Release Date :2012-12-06
  • Total pages :214
  • ISBN : 3642557015
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Summary : The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.

The River

The River
  • Author : Edward Hooper
  • Publisher :
  • Release Date :2000
  • Total pages :1118
  • ISBN : 9780316371377
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Summary : A British medical journalist offers a meticulously researched look at HIV and its potential source, discussing the history of this lethal epidemic, analyzing a number of theories concerning its origins, and investigating current scientific inquiries into HIV, AIDS, and the search for a cure. Reprint. 15,000 first printing.

The Cytokine Network

The Cytokine Network
  • Author : Frances R. Balkwill
  • Publisher :
  • Release Date :2000
  • Total pages :199
  • ISBN : 9780199637027
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Summary : Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy. They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokine receptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can be partially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeutic potential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immune response, and therapeutics.