Clinical And Translational Science

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Clinical and Translational Science

Clinical and Translational Science
  • Author : David Robertson,Gordon H. Williams
  • Publisher :
  • Release Date :2016-11-25
  • Total pages :808
  • ISBN : 012802111X
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Summary : Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Clinical and Translational Science

Clinical and Translational Science
  • Author : David Robertson
  • Publisher :
  • Release Date :2016-10-17
  • Total pages :616
  • ISBN : 9780128021019
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Summary : "Clinical and Translational Science: Principles of Human Research, Second Edition, " is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicineBrings insights from international leaders into the discipline of clinical and translational scienceAddresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
  • Author : Martin Wehling
  • Publisher :
  • Release Date :2015-04-02
  • Total pages :364
  • ISBN : 0128007214
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Summary : Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

The CTSA Program at NIH

The CTSA Program at NIH
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences
  • Publisher :
  • Release Date :2013-09-09
  • Total pages :178
  • ISBN : 0309284775
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Summary : In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

The CTSA Program at NIH

The CTSA Program at NIH
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences
  • Publisher :
  • Release Date :2013-10-09
  • Total pages :178
  • ISBN : 0309284740
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Summary : In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Translating Expertise

Translating Expertise
  • Author : Marisa L. Conte
  • Publisher :
  • Release Date :2016-08-29
  • Total pages :280
  • ISBN : 1442262680
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Summary : Translating Expertise: The Librarian’s Role in Translational Research provides background and context on the CTSA program. Case studies detail routes to librarian involvement in translational research, including collection development, relationships with researchers and administrators, instruction and training, data management, and team science.

NIH Administration of the Clinical and Translational Science Awards Program

NIH Administration of the Clinical and Translational Science Awards Program
  • Author : United States. Department of Health and Human Services. Office of Inspector General
  • Publisher :
  • Release Date :2011
  • Total pages :30
  • ISBN :
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Summary :

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
  • Author : N.A
  • Publisher :
  • Release Date :2019-03-22
  • Total pages :418
  • ISBN : 012817739X
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Summary : Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Pharmaceutical Medicine and Translational Clinical Research

Pharmaceutical Medicine and Translational Clinical Research
  • Author : Divya Vohora,Gursharan Singh
  • Publisher :
  • Release Date :2017-11-14
  • Total pages :526
  • ISBN : 0128020989
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Summary : Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery

Translational and Experimental Clinical Research

Translational and Experimental Clinical Research
  • Author : Daniel P. Schuster,William J. Powers (MD.)
  • Publisher :
  • Release Date :2005
  • Total pages :490
  • ISBN : 9780781755658
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Summary : This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
  • Author : Martin Wehling
  • Publisher :
  • Release Date :2015-04-02
  • Total pages :364
  • ISBN : 0128007214
GET BOOK

Summary : Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Progress in Molecular Biology and Translational Science

Progress in Molecular Biology and Translational Science
  • Author : David B. Teplow
  • Publisher :
  • Release Date :2018-10-16
  • Total pages :218
  • ISBN : 0128162368
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Summary : Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher :
  • Release Date :2015-12-01
  • Total pages :412
  • ISBN : 1498766579
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Summary : Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Clinical and Translational Medicine

Clinical and Translational Medicine
  • Author : Anna Garner
  • Publisher :
  • Release Date :2019-06-12
  • Total pages :239
  • ISBN : 9781632428400
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Summary : Clinical and translational medicine refers to the therapeutic clinical potential and application of translational research that seeks to develop the understanding of mechanisms and treatments of human diseases. The clinical variation between diseases, biomarkers, pathogenesis and therapies are also highlighted through studies of clinical and translational medicine. This is a critical and core component of the full-spectrum of biomedical research. Translational medicine refers to an area of research that seeks to determine the relevance of novel discoveries in the biological science to human disease. It also integrates new knowledge in clinical practice and clinical observations into scientific knowledge. Hence, translational research, facilitates the generation of novel hypotheses and disease characterization based on direct human observation. Translational medicine can work to expedite the incorporation of novel endpoints into clinical testing, thus shortening the duration of clinical trials. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of clinical and translational medicine. The ever growing need of advanced technology is the reason that has fueled the research in this field in recent times. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study.

Translational Informatics

Translational Informatics
  • Author : Philip R.O. Payne,Peter J. Embi
  • Publisher :
  • Release Date :2014-08-23
  • Total pages :185
  • ISBN : 1447146468
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Summary : Integrative and translational methodologies and frameworks have transformed modern biomedical research and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate knowledge translation, and initial efforts to deliver personalized healthcare informed by the genomic profiles of patients. A common theme of reports and publications concerned with such transformative changes in the biomedical and healthcare domains is concerned with the challenges and opportunities related to the collection, management, integration, analysis, and dissemination of large-scale, heterogeneous biomedical data sets. In particular, the absence of well-established and adopted theoretical and practical frameworks intended to address such needs is a major impediment to the realization of translational and knowledge-driven healthcare, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. This book details for the first time the current state of this extremely potent area of healthcare innovation and policy and defines the interaction between clinical/translational science and biomedical informatics.​

Pediatric Traumatic Brain Injury

Pediatric Traumatic Brain Injury
  • Author : Vicki Anderson,Keith Owen Yeates
  • Publisher :
  • Release Date :2010-02-04
  • Total pages :235
  • ISBN : 0521763320
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Summary : "This book, New Frontiers in Pediatric Traumatic Brain Injury, aims to evaluate what we have learned about TBI in childhood to date and, perhaps more importantly to articulate the challenges we face and how we should go forward in the future"--Provided by publisher.

Translational Pain Research

Translational Pain Research
  • Author : Lawrence Kruger,Alan R Light
  • Publisher :
  • Release Date :2009-11-24
  • Total pages :432
  • ISBN : 1439812101
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Summary : One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Clinical and Translational Perspectives on WILSON DISEASE

Clinical and Translational Perspectives on WILSON DISEASE
  • Author : Nanda Kerkar,Eve A Roberts
  • Publisher :
  • Release Date :2018-09-18
  • Total pages :502
  • ISBN : 012810533X
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Summary : Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate ‘basic science’ aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. Delivers numerous, succinct, expert chapters with summaries designed for quick reference Includes a 'How-to appendix' for diagnosis and management tips Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Translational Medicine: Tools And Techniques

Translational Medicine: Tools And Techniques
  • Author : Aamir Shahzad
  • Publisher :
  • Release Date :2015-11-24
  • Total pages :196
  • ISBN : 0128034947
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Summary : Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine. Includes detailed and standardized information about the techniques and tools used in translational medicine Provides specific industry case scenarios Explains how to use translational medicine tools and techniques to plan and improve infrastructures and capabilities while reducing cost and optimizing resources

Translational Medicine

Translational Medicine
  • Author : Dennis Cosmatos,Shein-Chung Chow
  • Publisher :
  • Release Date :2008-12-17
  • Total pages :224
  • ISBN : 9781584888734
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Summary : Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies that lead to regulatory approval of drug release to patients. Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research. Documents Alternative Research Approaches for Faster and More Accurate Data Judgment Calls Elaborating on how to introduce TM into clinical studies, this authoritative work presents a keen approach to building, executing, and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts. This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists, research executives, clinicians, and biostatisticians looking to expedite successful implementation of this important process.